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Editor's e-Note
A new technique, chemical exchange saturation transfer (CEST), that measures specific molecules in the body, may enhance clinical decision making in the treatment of patients with heart disorders, according to a recent study. The new MRI method maps creatine in the heart at higher resolutions to help clinicians detect abnormalities earlier than they can with traditional diagnostic methods.

The technique will allow physicians to pinpoint regional changes in the heart that occur after heart attacks, helping to identify and treat patients at risk of developing heart failure before symptoms develop. The increased sensitivity with CEST can help detect small damaged areas of the heart that may be missed by conventional imaging.

In addition to reading our e-newsletter, be sure to visit Today’s Geriatric Medicine’s website at www.TodaysGeriatricMedicine.com, where you’ll find news and information that’s relevant and reliable. We welcome your feedback at TGMeditor@gvpub.com. Follow Today’s Geriatric Medicine on Facebook and Twitter, too.

— Barbara Worthington, editor
e-News Exclusive
MRI-Measured Creatine Levels
May Detect Heart Problems Earlier


A new MRI method to map creatine at higher resolutions in the heart may help clinicians and scientists find abnormalities and disorders earlier than traditional diagnostic methods, researchers at the Perelman School of Medicine at the University of Pennsylvania suggest in a new study recently published online in Nature Medicine. The preclinical findings show an advantage over less sensitive tests and point to a safer and more cost-effective approach than those with radioactive or contrasting agents.

Creatine is a naturally occurring metabolite that helps supply energy to all cells through creatine kinase reaction, including those involved in heart contractions. When heart tissue becomes damaged from a loss of blood supply, even in the very early stages, creatine levels drop. Researchers exploited this process in a large animal model with a method known as chemical exchange saturation transfer (CEST), which measures specific molecules in the body, to track the creatine on a regional basis.

The team, led by Ravinder Reddy, PhD, a radiology professor and the director of the Center for Magnetic Resonance and Optical Imaging at Penn Medicine, found that imaging creatine through CEST MRI provides higher resolution compared with standard MR spectroscopy (MRS), a commonly used technique for measuring creatine.

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In this e-Newsletter
Tech & Tools
DVTCare System
The DVTCare System, a battery-powered intermittent pneumatic compression device, is an in-home technology designed to help reduce patients’ risk of developing deep vein thrombosis following hospital discharge. Learn more »

Neurometrix Sensus
Pain Management System

The Sensus Pain Management System is a device worn around the calf to alleviate the pain associated with diabetic peripheral neuropathy. The Sensus Ssystem uses transcutaneous electric nerve stimulation to deliver electric currents that stimulate nerves. The FDA has approved the use of the device during sleep, since it can sense electrode dislodgement and avoid electric risks. Learn more »
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Featured Jobs
The nation's top employers and recruiters of geriatric care professionals advertise in Today's Geriatric Medicine magazine and post their job openings on AlliedHealthCareers.com. Check out the most recent opportunities that have been submitted by employers across the country!
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The Frailty Syndrome
Physicians must understand the importance of identifying frail elders and the specialized treatment they require. Read more »

Interventions Bolster Fall Prevention
Individually tailored balance and strength exercise programs can effectively reduce older adults’ rates and risks of falling. Read more »

Alzheimer’s Disease and the Blood-Brain Barrier
Researchers are changing the way they think about the blood-brain barrier. Instead of being an enemy, it is now being thought of as an ally. Read more »
Other News
Independent Doctor Strives to Spend More Time With Patients
At a time when mandates and regulations seem to dictate the way physicians practice medicine, a Pennsylvania physician has succeeded in doing it his own way, according to an article in the Harrisburg Patriot News.

Medicare Identifies Best, Worst Hospitals for Hip, Knee Replacements
Read more about these hospitals in an article from The Philadelphia Inquirer.

More Alzheimer’s Patients Finding Care Far Overseas
An article at FoxNews.com describes desirable and effective Alzheimer’s care outside the United States that may be superior to and more affordable than similar caregiving offered in this country.

Doctors Stressed by Too Many Patients Offer 'Concierge' Care
The Orlando Sentinel looks at whether physicians, stressed by face time with patients and insurance payment constraints, are trending toward the practice of concierge medicine.
Ak the Expert
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