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Editor's e-Note
Estimates from the University of California-Los Angeles Health Sciences suggest that by 2060 about 15 million Americans will have mild cognitive impairment or Alzheimer’s disease (AD), a huge increase from 6.08 million in 2017. This striking increase highlights the urgent need to identify measures that could slow the progression of disease in people with indications of neuropathological changes that could lead to AD. While more work is necessary, researchers have found promise in a compound that targets the APOE protein in the brain.

In addition to reading our e-newsletter, be sure to visit Today’s Geriatric Medicine’s website at, where you’ll find news and information that’s relevant and reliable. We welcome your feedback at Follow Today’s Geriatric Medicine on Facebook and Twitter, too.

— Barbara Worthington, editor
e-News Exclusive
Targeting Protein Could Prevent Alzheimer’s Disease

People who carry the APOE4 genetic variant are at substantial risk for developing Alzheimer’s disease. Now researchers have identified a compound that targets the APOE protein in the brains of mice and protects against damage induced by the Alzheimer’s protein amyloid beta.

“Scientists have been interested in APOE for years, but there are only a few examples where researchers have targeted it with a compound in living animals,” says senior author David Holtzman, MD, a professor and head of the neurology department at Washington University in St. Louis and senior author of the study in Neuron.

“Our findings indicate that APOE is not just involved in Alzheimer’s risk and disease progression, but it could potentially be a real target for treatment or prevention,” Holtzman says.

Alzheimer’s disease, which affects one in 10 people over the age 65, is marked by brain plaques made of a sticky protein known as amyloid beta. The plaques start forming in the brain years before the characteristic symptoms of memory loss and confusion appear. APOE4 raises the risk of Alzheimer’s partly by encouraging amyloid beta to collect into damaging plaques.

Full story »
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Featured Jobs
The nation's top employers and recruiters of geriatric care professionals advertise in Today's Geriatric Medicine magazine and post their job openings on Check out the most recent opportunities that have been submitted by employers across the country!

Geriatric Consultation Position
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Recently approved by the FDA, the FreeStyle Libre Flash Glucose Monitoring System is the first sanctioned device to monitor blood glucose in adult patients with diabetes without the need for a finger prick. The system uses a small sensor implanted beneath the skin and a mobile reader to continuously monitor blood glucose. The device produces no type of alarm or alert if blood glucose levels are inappropriate. It eliminates the need for painful finger pricks. Learn more »

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