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Editor's e-Note
Mayo Clinic researchers have discovered that men with low-risk prostate cancers identified through needle biopsy may in fact have high-risk cancer in the prostate. Identification of genetic alterations can reveal cases of high-risk cancers that are missed by biopsy, according to their study, published in the January edition of Mayo Clinic Proceedings. Additional testing for these molecular markers can help guide treatment decisions.

In addition to reading our e-newsletter, be sure to visit Today’s Geriatric Medicine’s website at, where you’ll find news and information that’s relevant and reliable. We welcome your feedback at Follow Today’s Geriatric Medicine on Facebook and Twitter, too.

— Kate Jackson, editor
e-News Exclusive
Mayo Clinic Discovers Biological Markers That Could Guide Treatment for Prostate Cancer

Genetic alterations in low-risk prostate cancer diagnosed by needle biopsy can identify men that harbor higher-risk cancer in their prostate glands, Mayo Clinic has discovered. The research, which is published in the January edition of Mayo Clinic Proceedings, found for the first time that genetic alterations associated with intermediate- and high-risk prostate cancer also may be present in some cases of low-risk prostate cancers.

The study found the needle biopsy procedure may miss higher-risk cancer that increases the risk of disease progression. Researchers say that men diagnosed with low-risk cancer may benefit from additional testing for these chromosomal alterations.

“We have discovered new molecular markers that can help guide men in their decisions about the course of their prostate cancer care,” says George Vasmatzis, PhD, codirector of the Center for Individualized Medicine Biomarker Discovery Program and lead author on the study. “Overtreatment has been issue for the group of men that our study targets. We found that the presence of genetic alterations in low-risk cancer can help men decide whether treatment or active surveillance is right for them.”

Full story »
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