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Editor's e-Note
According to research published in Diabetes Care, when metformin fails to control disease in patients with type 2 diabetes, a combination of two drugs—dapagliflozin and exenatide—may provide better glycemic control than does either drug alone. Moreover, according to the multicenter double-blind, phase 3, randomized control trial, the benefit extends for more than two years.

In addition to reading our e-newsletter, be sure to visit Today’s Geriatric Medicine’s website at, where you’ll find news and information that’s relevant and reliable. We welcome your feedback at Follow Today’s Geriatric Medicine on Facebook and Twitter, too.

— Kate Jackson, editor
e-News Exclusive
Combo Drug Treatment for Diabetes

Patients with type 2 diabetes often take metformin as first-line therapy to help stabilize their blood glucose. Eventually, some patients no longer respond to metformin and require additional treatment. A few years ago, pivotal short-term trials showed that a combination of two drugs controlled diabetes progression better than either single drug alone. Now, new research demonstrates that this drug combo of dapagliflozin and exenatide continues to stay effective, without loss of effect, after two years of continual use.

“Many therapies in diabetes management are short-lived, which is why it’s useful to test for long-term effect,” says senior author Serge Jabbour, MD, director of the division of endocrinology and the Diabetes Center at Thomas Jefferson University in Philadelphia. “Our study showed that a combo regimen of dapagliflozin and exenatide continued to control patients’ glucose for over two years. This is very encouraging.”

The results of this multicenter double-blind, phase 3, randomized controlled trial were recently published in the journal Diabetes Care.

Full story »
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Brain Fog After COVID-19
After being critically ill from COVID-19, many older adults are experiencing sudden cognitive dysfunction. Zijian Chen, MD, medical director of the Center for Post-COVID Care at Mount Sinai Health System in New York says they’re describing memory disturbances, difficulty concentrating, and an inability to gather their thoughts—these on top of the other physical sequelae of the illness, The Philadelphia Inquirer reports.

COVID’s Effect on the Brain
Another finding related to cognitive abilities among older adults who’ve had COVID-19, according to a questionnaire surveying 84,000 people in the United Kingdom, is that the brains of some who had or suspected they were infected by the virus appear to have aged by about 10 years, Newsweek reports. While the research was not peer reviewed, it suggests an area of concern and indicated a need for further research.

Positive Aging
Can a positive attitude be an inoculation against memory loss? Research published in Psychological Science suggests that those who have “positive affect”—feelings of cheerfulness and enthusiasm—may experience less memory loss as they age than others without such a temperament, ScienceDaily reports.
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