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Editor's e-Note
Despite surgery, patients with stage 3 melanoma commonly have a poor prognosis. Those who are given immunotherapy in an adjuvant setting after surgery have improved survival, according to research recently presented at the American Association for Cancer Research Virtual Annual Meeting II. “Based on our findings, immunotherapy after resected stage 3 melanoma appears to reveal a trend for real-world 24-month survival advantage compared with no therapy, supporting the role of adjuvant immunotherapy in the real-world setting,” says Justin Moyers, MD, a fellow at Loma Linda University in California.

In addition to reading our e-newsletter, be sure to visit Today’s Geriatric Medicine’s website at, where you’ll find news and information that’s relevant and reliable. We welcome your feedback at Follow Today’s Geriatric Medicine on Facebook and Twitter, too.

— Kate Jackson, editor
e-News Exclusive
Improving Outcomes for Patients With Stage 3 Melanoma

Data derived from a large real-world database showed that some US patients with stage 3 melanoma receive adjuvant immunotherapy (immunotherapy after surgery), and those receiving adjuvant immunotherapy had improved survival compared with those who did not, according to a study recently presented at the American Association for Cancer Research Virtual Annual Meeting II.

“Patients with stage 3 melanoma tend to have poor prognosis even after curative-intent surgery,” says Justin Moyers, MD, a fellow at Loma Linda University in California. In 2015, the immune checkpoint inhibitor ipilimumab (Yervoy) was approved by the FDA as adjuvant treatment to reduce the risk of melanoma returning after surgery. Data from ipilimumab clinical trials have shown that it improves survival in patients with stage 3 melanoma when given in an adjuvant setting after resection, Moyers notes.

“The goal of our study was to determine the percentage of patients receiving immunotherapy after surgery in the era of FDA approval for adjuvant checkpoint inhibitors following surgical resection in the real-world setting,” Moyers says. “We also aimed to see the 24-month survival rate of those receiving immunotherapy vs those who did not.”

Moyers and colleagues utilized data from the National Cancer Database, a joint project of the Commission on Cancer (CoC) of the American College of Surgeons and the American Cancer Society. It is a clinical oncology database, and the data are used to analyze and track patients with malignant neoplastic diseases, treatments, and outcomes. The database is the largest clinical cancer registry in the world, covering 72% of new cancer diagnoses in the United States, Moyers says.

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