Creative Nutrition: Solutions for Failure-to-Thrive Patients
Ensure adequate access to food, provide a pleasant dining experience with adequate assistance to eat, and offer favorite foods.
The term “failure to thrive” (FTT) has been used to describe older adults who were once active and are now socially withdrawn, lonely, bored, and depressed. FTT in older adults has been described as “a syndrome manifested by weight loss greater than 5% of baseline, decreased appetite, poor nutrition, and inactivity, often accompanied by dehydration, depressive symptoms, impaired immune function, and low cholesterol levels.”1 It may result from issues such as chronic disease and functional decline, physical and emotional deprivation, poor appetite, poor diet, or medical problems.2-4 All of these combined can easily lead to inadequate food intake, malnutrition, unintended weight loss, weakness, functional decline, and other complicating factors such as falls, impaired immune response, and poor wound healing.
FTT affects 5% to 35% of community-dwelling older adults and 25% to 40% of nursing home residents. Its prevalence appears to increase with age. Studies indicate that it is associated with decreased immunity and increased rates of infection, incidence of hip fractures, pressure ulcers, surgical mortality, mortality rates, and medical costs.2
FTT is not a normal consequence of aging or chronic disease, and caution should be used in applying the geriatric FTT label. It should not be treated as a diagnosis or a disease or equated with frailty, and it should not signal the withdrawal of efforts to find and treat underlying causes. Instead it should be viewed as an unexpected and significant change in normal health status, a decline in vigor, weight, and function that can affect even the healthiest of older adults. For older patients exhibiting an unintended reduction of food intake, unintended weight loss, decline in the ability to provide self-care, a decline in cognitive function, and a general decline in interest in daily life, the term “failure to thrive” should trigger a thorough evaluation to determine possible reversible underlying causes.3
Identification and Assessment
A thorough medical evaluation should include a total review of psychosocial, economic, spiritual, and emotional needs and social/environmental factors. Living situation, caregiver ability, potential abuse or neglect, isolation, the financial ability to purchase food and prescriptions, and alcohol and substance abuse can all have dramatic effects on older adults’ ability to thrive.4 Assessment must also include the evaluation of functional ability, underlying medical problems, and medication interactions; a nutrition assessment; and appropriate laboratory and radiological evaluations individualized to a patient’s specific needs.2
Medical conditions associated with FTT can include cancer, congestive heart failure, chronic lung disease, chronic renal insufficiency, chronic steroid use, cirrhosis, cardiovascular accident, depression or other psychological disorders, diabetes, hepatitis, hip or large bone fracture, inflammatory bowel disease, a history of gastrointestinal (GI) surgery, myocardial infarction, recurrent urinary tract infection, recurrent pneumonia, rheumatologic disease (eg, rheumatoid arthritis, lupus), a systemic infection, or tuberculosis.2 Dentition, vision, hearing, continence, and GI issues must also be addressed.
A review of medications should include drug-nutrient interactions, drug-drug interactions, polypharmacy, and adverse side effects of medication, which can all have devastating effects on older adults. Medications associated with FTT include anticholinergic drugs, antiepileptic drugs, benzodiazepines, beta-blockers, central alpha-antagonists, diuretics in high potency combinations, glucocorticoids, neuroleptics, opioids, selective serotonin reuptake inhibitors, tricyclic antidepressants, and any combination of more than four prescription medications.2
Along with an in-depth evaluation of the factors mentioned above, it is imperative to assess four main areas of FTT syndrome: impaired physical function or status, undernutrition or malnutrition including unintended and/or significant weight loss, depression or depressive symptoms, and cognitive impairment or decline.2,4
Impaired Physical Function or Status
Undernutrition or Malnutrition
Depression or Depressive Symptoms
Cognitive Impairment or Decline
Nutritional status has a significant impact on an elder’s ability to recover and rehabilitate from illness, injury, or surgery. Malnourished older adults have diminished muscle strength, which can lead to weakness, decreased independence, and falls. They may recover more slowly from illness or acute episodes or experience unintended weight loss, increased risk of pressure ulcers, poor healing rates, anemia, fatigue, susceptibility to infection due to immune dysfunction, and ultimately increased morbidity and mortality.
Identifying protein energy malnutrition can be difficult. Historically, serum albumin has been used to assess nutrition status, but recent literature does not support this use. Low albumin may be related to the effects of inflammation and/or chronic disease (eg hepatic disease, kidney disease) and does not necessarily correlate with poor nutritional status.5,6 However, low serum albumin is associated with lower survival rates and it is important to assess overall nutritional status in individuals with high morbidity risk.6
Loss of muscle mass is an indicator of protein-energy malnutrition. Sarcopenia (loss of muscle associated with aging) can exacerbate the difficulties challenging the health of an older adult above and beyond issues related to FTT. Generally, people start losing muscle at about the age of 45 and tend to continue losing muscle at a rate of about 1% per year. This muscle loss leads to decreased strength and ability to perform everyday tasks. In addition, unsteadiness may result in falls. There is some evidence that physical activity and protein intake can help prevent or slow the progression of sarcopenia, according to the second edition of the Handbook of Clinical Nutrition and Aging.
Other factors that accelerate loss of muscle mass in older adults include decreased physical activity, testosterone and growth hormone deficiency, possibly mild cytokine excess, and the stress response.7 The stress response is a hormonal response (ie, a heightened fight-or-flight response) due to catabolic illness such as wounds, trauma, surgery, or infection that increases energy needs, causes the body to break down proteins and lean body mass (LBM), and can lead to protein energy malnutrition.8
LBM makes up 75% of body weight, mostly in the form of muscle, bone, and tendon, and provides the majority of the body’s protein. Loss of just 10% of LBM decreases immune response and increases the risk for infection. With an LMB loss of 15% or more, the rate of wound healing decreases and weakness increases. At 30% loss, pressure ulcers may develop and healing response is nonexistent. A 40% LBM loss usually results in death (often due to pneumonia).8 Unfortunately, the rate of LBM recovery is much slower during the recovery stage than the rate of loss during the inflammatory stage.
Medical Nutrition Therapy
One of the most important nutrition interventions is to ensure adequate calorie and protein intake. This can be achieved by ensuring adequate access to food, providing a pleasant dining experience with adequate assistance to eat, offering favorite foods, individualizing to the least restrictive diet appropriate, using enhanced or fortified foods, providing oral nutritional supplements, and using appetite stimulants or enteral feeding if appropriate.
• 25 to 35 kcal/kg/day for women and 30 to 40 kcal/kg/day for men for healthy older adult weight maintenance;
• 30 to 35 kcal/kg/day for individuals under stress with pressure ulcers;
• 21 kcal/kg/day for a population that is obese and/or critically ill;
• 28 kcal/kg/day for paraplegics; and
• 23 kcal/kg/day for quadriplegics.9-12
It is important to ensure adequate protein intake to slow sarcopenia, decrease the loss of LBM, and avoid protein energy malnutrition by following these recommendations:
• maintaining 1 to 1.2 g/kg of body weight in nonstressed patients;
• maintaining 1.25 to 1.5 g/kg of body weight for patients with pressure ulcers or who are under stress; and
• maintaining 0.8 g/kg of body weight in patients with chronic renal failure (predialysis).9,11,13
Some older adults need vitamin and/or mineral supplementation. A daily multivitamin/mineral supplement is suggested for most older adults with poor food and/or fluid intake.8 Individuals who experience anorexia, food aversions, or loss of appetite may benefit from alternative interventions such as appetite stimulants or enteral feeding if they’re in the best interest of the patient and in accordance with goals and desires.
Physical Activity and Nutrition: A Winning Combination
Nearly all older adults can benefit from resistance and strength training to increase muscle strength, improve functional ability, and prevent further decline. Include the following four components of physical activity for a well-balanced exercise plan:
• Endurance to improve the cardiovascular and circulatory systems (low-impact exercises).
• Strength to reduce sarcopenia, build muscle, and possibly prevent osteoporosis. Strength training can include resistance training three times per week. Tylenol or a nonsteroidal anti-inflammatory agent may be needed prior to exercise to reduce postworkout pain from inflammation.8 Alone and in combination with nutritional supplementation, strength training increases strength and functional capacity.15
• Balance to prevent falls. Balance exercises may include tai chi (improves balance) or something as simple as standing on one leg with eyes closed, though older adults may need to hold on to something while doing this.
• Flexibility to recover from or prevent injuries may help prevent falls (ie, yoga or stretching exercises), according to the NIH.
Nutrition and exercise together have a synergistic effect that helps combat malnutrition, increase strength, and promote well-being. Encourage physical activity and suggest age- and ability-appropriate exercises, including walking and strength training. Refer patients to a physical therapist to assess range of motion, strength, and endurance and to determine the need for assistive devices such as canes, walkers, grab bars, or shower chairs. Determine whether an elder can benefit from continued physical therapy, occupational therapy, or strength training and refer to social services for a home environment assessment as appropriate.
— Becky Dorner, RD, LD, is founder/president of Becky Dorner & Associates, Inc, a dietetic education/information firm, and Nutrition Consulting Services, Inc, a dietetic consulting firm, both based in Akron, Ohio. Her website is www.beckydorner.com.
2. Robertson RG, Montagnini M. Geriatric failure to thrive. Am Fam Physician. 2004;70(2):343-350.
3. Woolley DC. How useful is the concept of ‘failure to thrive’ in care of the aged? Am Fam Physician. 2004;70(2):248,257.
4. Lantz MS. Psychiatry rounds: Failure to thrive. Clinical Geriatrics. 2005;13(3):20-23.
5. Mitchell-Eady CO, Chernoff R. Nutritional assessment of the elderly. In: Chernoff R (ed). Geriatric Nutrition: The Health Professional’s Handbook. 3rd ed. Sudberry, Mass.: Jones and Bartlett Publishers; 2006.
6. Furhman PM, Charney P, Mueller CM. Hepatic proteins and nutrition assessment. J Am Diet Assoc. 2004;104(8):1258-1264.
7. Morley JE, DiMaria RA, Amella E. Frailty and the older adult: Features, vulnerabilities, and feeding. Clinical Nutrition Week. January 30, 2005.
8. Demling RH, DeSanti L. Involuntary weight loss and the nonhealing wound: The role of anabolic agents. Adv Wound Care. 1999;12(Suppl 1):1-14.
9. Piland C, Adams K, eds. Pocket Resource for Nutrition Assessment. Chicago: American Dietetic Association; 2009.
10. Litchford M. The Advanced Practitioner’s Guide to Nutrition and Wounds. Greensboro, N.C.: Case Software and Books; 2009.
11. Dorner B, Posthauer ME, Thomas D. The role of nutrition in pressure ulcer prevention and treatment: National Pressure Ulcer Advisory Panel White Paper. 2009. Available at: http://www.npuap.org/Nutrition White Paper Website Version.pdf
12. American Dietetic Association Evidence Analysis Library, Unintended weight loss in older adults. Available at: http://www.adaevidencelibrary.com/topic.cfm?cat=2948. Accessed August 4, 2010.
13. Niedert KC, Dorner B, eds. Nutrition Care of the Older Adult: A Handbook for Dietetics Professionals Working Throughout the Continuum of Care. Chicago: American Dietetic Association; 2004.
14. Federal Interagency Forum on Aging Related Statistics. Older Americans 2008: Key Indicators of Well-Being. Washington, D.C.: U.S. Government Printing Office; 2008.
15. Mead Johnson Advisory Board for Geriatric Health and Nutrition. Recuperative powers of nutrition: Resistance, recovery, rehabilitation monograph. Mead Johnson Nutritionals, Mead Johnson & Company, 2003.
• Launch a thorough investigation of older adults who experience decline in vigor, weight, or function.
• Examine older adults’ psychosocial, economic, spiritual, and emotional needs as well as social/environmental factors.
• Review medications to identify possible drug-nutrient interactions, drug-drug interactions, polypharmacy, and adverse side effects of medications.
• Identify nutritional deficits and make appropriate diet modifications.
• Encourage exercise to improve endurance, strength, balance, and flexibility.