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Researchers Identify First Brain Training Exercise Positively Linked to Dementia Prevention

Aging research specialists have identified, for the first time, a form of mental exercise that can reduce the risk of dementia. 

The cognitive training, called speed of processing, showed benefits up to 10 years after study participants underwent the mental exercise program, says Frederick W. Unverzagt, PhD, a professor of psychiatry at Indiana University School of Medicine.

The proportion of participants who underwent the training and later developed dementia was significantly smaller than among those who received no cognitive training, the researchers say.

There were measurable benefits even though the amount of training was small and spread out over time: 10 one-hour sessions over six weeks initially and up to eight booster sessions after that.      

"We would consider this a relatively small dose of training, a low intensity intervention. The persistence— the durability of the effect was impressive," says Unverzagt, who explains more in a Q&A blog post.

Results from the Advanced Cognitive Training in Vital Elderly (ACTIVE) study of 2,802 older adults were recently reported in Alzheimer & Dementia Translational Research and Clinical Interventions, a peer-reviewed journal of the Alzheimer's Association.

The researchers, from IU, the University of South Florida, Pennsylvania State University, and Moderna Therapeutics, examined healthy adults aged 65 years and older from multiple sites and who were randomly assigned to one of four treatment groups:

  • Participants who received instructions and practice in strategies to improve memory of life events and activities.
  • Participants who received instruction and practice in strategies to help with problem solving and related issues.
  • Participants who received computer-based speed of processing exercises—exercises designed to increase the amount and complexity of information they could process quickly.
  • A control group whose members did not participate in any cognitive training program.

Initial training consisted of 10 sessions lasting about an hour, over a period of five to six weeks. A subset of participants who completed least 80% of the first round of training sessions were eligible to receive booster training, which consisted of four 60- to 75-minute sessions 11 months and 35 months following the initial training. Participants were assessed immediately after training and at one, two, three, five, and 10 years after training.

After attrition due to death and other factors, 1,220 participants completed the 10-year follow-up assessment. During that time, 260 participants developed dementia. The risk of developing dementia was 29% lower for participants in speed of processing training than for those who were in the control group, a statistically significant difference. Moreover, the benefits of the training were stronger for those who underwent booster training. While the memory and reasoning training also showed benefits for reducing dementia risk, the results were not statistically significant.

Unverzagt noted that the speed of processing training used computerized "adaptive training" software with touch screens. Participants were asked to identify objects in the center of the screen, while also identifying the location of briefly appearing objects in the periphery. The software would adjust the speed and difficulty of the exercises based on how well participants performed.

In contrast the memory and reasoning programs used more traditional instruction and practice techniques as might occur in a classroom setting.

Earlier studies had shown that ACTIVE cognitive training improved participants' cognitive abilities and the ease of engaging in activities of daily living five and 10 years after the initial training.  However, an examination of the role of ACTIVE cognitive training on dementia incidence was not significant after five years of follow-up. 

The ACTIVE study was supported by grants from the National Institute of Nursing Research (U01 NR04508, U01 NR04507) and the National Institute on Aging (U01 AG14260, U01 AG 14282, U01 AG 14263, U01 AG14289, U01 AG 014276). The newly reported analyses of the impact on dementia were supported by the Indiana Alzheimer Disease Center (P30AG10133) and the Cognitive and Aerobic Resilience for the Brain Trial (R01 AG045157).

In addition to Dr. Unverzagt, researchers involved in the study were first author Jerri D. Edwards of the University of South Florida, Huiping Xu and Daniel O. Clark of IU School of Medicine, Lin T. Guey of Moderna Therapeutics of Cambridge, Mass., and Lesley A. Ross of the Pennsylvania State University.

Source: Indiana University