Deep Brain Stimulation Showing Promise for Patients With Mild Alzheimer's Disease Over Age 65
An age group analysis of data from the ADvance trial has shown that participants over the age of 65 continue to derive the most benefit from deep brain stimulation of the fornix (DBS-f), as observed in the data from the phase 2 findings (12–24 months) of the Phase II trial.
The findings, published in the Journal of Alzheimer's Disease, by a team of researchers led by Andres Lozano, MD, PhD, at Toronto Western Hospital's Krembil Neuroscience Centre, are the potential beginnings of a patient profile for DBS-f treatment for Alzheimer's disease. The neurology and psychology aspects of the trial in Toronto were led by Toronto Western Hospital neurologist David Tang-Wai, MD, and neuropsychologist Mary Pat McAndrews, PhD, respectively.
To further explore the benefits for this demographic, the research team is soon launching a Phase III, multicenter international trial that will study the effects of DBS-f in 140 patients over age 65.
"We are encouraged by these findings as they continue to help us identify who will benefit most from DBS to treat Alzheimer's disease and learn more about this illness," says Lozano, a neurosurgeon and the principal investigator of the study. "With so few treatments available and the incidence of Alzheimer's only expected to increase, we really need to fully explore all treatments that seem to be of benefit to patients."
These latest results were captured from the second year of data of the ADvance trial whose first-year data were published in 2016. In that trial, 42 patients with mild Alzheimer's disease were enrolled in a randomized, double-blind multicenter phase II clinical trial and implanted with DBS electrodes directed at the fornix—a bundle of nerve fibers in the brain that carry signals from the hippocampus—and followed for a total of two years.
In the first 12 months of the trial, to better measure the impact of electrical stimulation in the brain, patients were randomly assigned to either the "on" or "off" stimulation group after their procedure and monitored. Once this phase of follow up was complete, all patients then had their electrodes turned on, and were followed for another 12 months.
In the second 12-month phase, researchers noted similar observations they had seen in the first phase: that, although there were no differences overall in cognitive outcomes between study participants who had their device turned on right after surgery and those who had it turned on after 12 months, those 65 years of age and older appeared to experience a slower progression of Alzheimer's than those under that age, regardless of when their device was turned on.
"The next phase of our research will help determine whether this observed benefit is something we continue to see in this age group," says Lozano, who is also a professor and chairman of the department of neurosurgery at the University of Toronto. "If it does, this could potentially give us a treatment for mild, late-onset Alzheimer's disease."
Source: University Health Network